Cisplatin ic50

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August undefined, 2024

WebAfter an incubation with DDP/EXOs, the cell lines exhibited a higher IC50 value for cisplatin, P-gp expression, migration and invasion capabilities and a lower apoptosis … WebDownload scientific diagram Summary of IC50 values of sinomenine or cisplatin in gastric cancer cells. from publication: Sinomenine sensitizes human gastric cancer cells to …

AID 625684 - Ratio of cisplatin IC50 to compound IC50 for

WebJun 5, 2024 · We first analyzed the correlation between TFEB expression and half maximal inhibitory concentration (IC50) of CDDP using Genomics of Drug Sensitivity in Cancer … WebCombination therapy of cisplatin and resveratrol to induce cellular aging in gastric cancer cells: Focusing on oxidative stress, and cell cycle arrest . × Close Log In. Log in with Facebook Log in with Google. or. Email. Password. Remember me on this computer. or reset password. Enter the email address you signed up with and we'll email you a ... can shoulder issues cause neck pain

Comparative evaluation of cisplatin and carboplatin sensitivity in ...

WebJun 1, 2024 · The cisplatin IC50 of the MBA-MB-231 and MCF-7 cell lines decreased from 60 μmol/L to 40 μmol/L and from 40 μmol/L to 20 μmol/L, respectively. Similarly, the doxorubicin IC50 of the MBA-MB-231 and MCF-7 cell lines decreased from 15 μmol/L to 7.5 μmol/L and 5 μmol/L to 3 μmol/L, respectively. WebApr 11, 2024 · IC50 was calculated with non-linear regression, and the survival rates were analyzed by log-rank test. The difference thresholds were set at p -value less 0.05 and p -value less 0.01. 3 Results 3.1 Proliferation of GC cells in alginate-based microspheres (core) WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. can shoulder issues cause arm pain

IC 50 values for cisplatin, curcuminoid, and combination …

Molecules Free Full-Text The Challenging Treatment of Cisplatin ...

WebIC50 values were calculated. Evaluation of apoptosis and DNA damage were performed. In addition, the expression of pro-apoptotic and anti-apoptotic genes and proteins were tested. IC50 values indicated less toxicity of the Schiff base … WebBackground: Cisplatin (Cp) is an antineoplastic agent with a dose-limiting nephrotoxicity. Cp-induced nephrotoxicity is characterized by the interplay of oxidative stress, inflammation, and apoptosis. can shoulder impingement cause severe painWebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying … can shoulder injury cause armpit pain

"WebAug 13, 2024 · CCK8 assay demonstrated that the half-maximal inhibitory concentration (IC50) of paclitaxel was 22.61 nM and 101.4 nM for NCI-H1975 and NCI-H1299 cells, … " - Cisplatin ic50

Cisplatin ic50

TP53TG1 enhances cisplatin sensitivity of non-small cell lung …

WebJun 15, 2024 · Methods: In this study, real-time quantitative PCR (RT-qPCR) and Western blotting (WB) were performed for detecting the expressions of miR-133b, fibroblast growth factor receptor 1 (FGFR1), and Wingless/Integrated (Wnt)-β-catenin pathway markers (Wnt1, β-catenin, nuclear-β-catenin, p-GSK-3β, GSK-3β, cyclinD1, and FOXQ1). WebNational Center for Biotechnology Information

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WebOverexpressing miR-515-5p markedly reduced cisplatin and 5-Fu IC50 values in HK-1/CDDP and CNE-1/CDDP cells, while IL-25 transfection was sufficient to reverse this phenotype (Figure 4E and F). As such, our data demonstrate that circNRIP1 enhances 5-Fu and cisplatin resistance in NPC cells at least in part via sequestering miR-515-5p and ... WebThe 50 % inhibitory concentration (IC50) of cisplatin in A549 and A549/DDP cells 48 h after drug treatment Source publication +4 RNA interferences targeting the Fanconi …

WebAug 13, 2024 · Cell Death & Disease - Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells. Skip to main content. ... (IC50) of paclitaxel was ... WebAug 27, 2024 · The combination of sodium butyrate with cisplatin decreased the IC50 value of cisplatin and attenuated the cytotoxic effect of cisplatin on the normal cells. Accordingly, we selected SGC-7901 cells and HGC-27 cells, which showed better sensitivities to sodium butyrate to perform the subsequent experiments.

WebSep 1, 2015 · Cisplatin, an alkylating agent has been successfully used since decades for the treatment of variety of cancers viz. bone cancer, lung cancer, head and neck cancer, … WebJan 10, 2024 · The half maximal inhibitory concentration (IC50) of different OC cells after treatment with ( a) olaparib, ( b) niraparib and ( c) rucaparib, assessed by clonogenic assays. Data represents the mean ± SEM of triplicates of …

WebApr 11, 2024 · Group division and overview of cells’ IC50 value of cisplatin 661 cell lines were finally enrolled with the complete data of mRNA, microRNA expression, and metabolite. They were divided into 3 groups according to the IC50 value, the half inhibitory concentration, given by the CCLE database, which reflects the sensitivity to …

WebFeb 5, 2016 · Cisplatin remains to be primary chemotherapeutic drug for gastric cancer patients, especially for advanced stage ones. However, primary or acquired resistance … can shoulder impingement cause chest painWebThe results of the present study show that 0.33 μmol/L cisplatin (IC 50) increased MN frequency by 2.5 times, compared to the non-treated control group. This indicates that cisplatin causes chromosomal mutations … flannel with jacket shirt style menWebApr 2, 2024 · IC50 values for ( a–d) bortezomib- and ( e–h) cisplatin-treated MCF7, HCC38, MCF-10A, and MDA-MB-436 breast cancer cells … flannel with jean collarWebDrug: Cisplatin - Cancerrxgene - Genomics of Drug Sensitivity in Cancer Genomics of Drug Sensitivity in Cancer Compound: Cisplatin Drug Target: DNA crosslinker Drug Target … STR profiles of cell lines Cell line authentication. Concerns around the … The IC50 and AUC are estimated using a non-linear mixed effect model fitting a … Users have a non-exclusive, non-transferable right to use data files for … can shoulder pain be heart relatedWebFeb 28, 2024 · All the new complexes showed cytotoxicity in vitro against the three cancer cell lines, but only complex 1a showed statistically significant different activity compared with cisplatin, with significantly lower IC 50 values, 4.31, 6.23, and 4.80 μM, compared with 9.71, 14.48, and 11.59 μM for cisplatin against A549, SKOV3, and MCF-7, respectively. can shoulder impingement cause neck painWebA cisplatin-resistant cell subline, HeLa/CDDP cells, showed a 19-fold resistance to cisplatin compared with the parent cells. The subline showed a collateral sensitivity to … can shoulder pain be cancerWebSome scientists established EC50 for cisplatin in SKOV-3 cell line, and it varied from 2 to 40 uM. However, in this publication there are some interesting data regarding that … flannel with jacket vest