Cisplatin sensitivity

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August undefined, 2024

WebWorldwide, the number of cancer-related deaths continues to increase due to the ability of cancer cells to become chemotherapy-resistant and metastasize. For women with ovarian cancer, a staggering 70% will become resistant to the front-line therapy, cisplatin. Although many mechanisms of cisplatin resistance have been proposed, the key mechanisms of … WebJun 24, 2011 · ICL-based chemotherapy is one of the most widely used forms of cancer treatment, particularly in the treatment of leukaemias. Fanconi anaemia (FA) is a disorder that results in sensitivity to...

Cisplatin Sensitivity in Hmgb1−/− and Hmgb1+/+ Mouse Cells*

WebApr 1, 2024 · Abstract. NKX2-1 was shown to enhance cisplatin sensitivity in KRAS-mutated cells, but it conferred cisplatin resistance in EGFR-mutated lung adenocarcinoma … WebJul 26, 2024 · Background: Cisplatin (CDDP) is commonly used to treat non-small cell lung cancer (NSCLC), but the appearance of drug resistance greatly hinders its … how many days is the moon waxing

Uptake of the anticancer drug cisplatin mediated by the copper ... - PNAS

WebNational Center for Biotechnology Information WebFor the first time, our study implies that d-borneol enhanced cisplatin sensitivity by inducing ferroptosis, promoting autophagy and inhibiting EMT progression, thereby … WebDec 7, 2024 · TTK silencing increased cisplatin sensitivity by activating the mammalian target of rapamycin (mTOR) complex to further suppress cisplatin-induced … how many days is the ryder cup

Bonn researchers elucidate a mechanism underlying cisplatin …

Identification of Three Human POLH Germline Variants Defective …

Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need … WebMay 1, 2003 · In such an instance, cancer cells may escape the apoptotic consequence of cisplatin exposure but still sustain major genotoxic insults. Considering that apoptosis … high speed mesh wifiWebSep 30, 2013 · In cisplatin-sensitive TC cell lines and the EC component of chemo-sensitive tumours, low levels of cytoplasmic p21 similarly correlated with high expression of Oct4 and of miRs belonging to the miR-17/106b seed family (Ref. Reference Koster40). P53 activity can be influenced by MDM2. how many days is the state fair

"WebFinally, an autophagy assay followed by western blotting was performed to study the effects of co-knockdown genes on cell autophagy in the presence and absence of cisplatin. … " - Cisplatin sensitivity

Cisplatin sensitivity

Targeting HNRNPU to overcome cisplatin resistance in bladder …

WebAug 1, 1996 · Purpose: Human glioma cell lines resistant (U373MGCP) and sensitive (U373MG) to cisplatin were used to evaluate the effect of cisplatin as a sensitizer to … WebFactors contributing to the observed cisplatin sensitivity include defective DNA damage repair and a hypersensitive apoptotic response to DNA damage. Nonetheless, around 10 …

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WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. ... USP14 levels were higher in DDP-resistant lung cancer compared to DDP-sensitive lung ... WebAbstract. Background: Hypersensitivity reactions to platinum salts (PS) (cisplatin [CI], carboplatin [CA], and oxaliplatin [OX]) can be severe and their incidence is increasing …

WebSep 24, 2024 · Cisplatin exerts anticancer activity via multiple mechanisms. Its most acceptable mechanism involves the formation of DNA–platinum adducts by interacting with purine bases, activating several signal transduction pathways, and silencing or activating several genes which finally leads to apoptosis. WebMar 15, 2003 · Cisplatin-resistance cell lines CP70, C30, and C200 were produced by intermittent, incremental exposure of the sensitive parental A2780 cell line to various concentrations of cisplatin. OVCAR-4 and OVCAR-10 cell lines were developed from patients who were clinically refractory to platinum-based chemotherapy (16, 17).

WebAug 24, 2024 · Cisplatin (CDDP) remains one of the most widely used first-line drugs in the therapy of NSCLC, based on the clinical data that the poor outcomes of untreated …

WebThere is no relationship between the presence or severity of Cisplatin side effects and effectiveness of cisplatin. The following side effects are common(occurring in greater than 30%) for patients taking Cisplatin: Nausea and vomiting. Nausea may last up …

WebMar 15, 2024 · The results indicated that URI knockdown increased the sensitivity of cells to cisplatin by inhibiting proliferation and promoting apoptosis. The levels of P-ATM, P-CHK2 and γH2AX were detected by Western blot. Increased levels of P-ATM, P-CHK2, and γH2AX were observed in cisplatin treated cells, indicating that cisplatin induced a DNA … how many days is the nba draftWebMay 18, 2024 · Cisplatin is the first-line platinum-based chemotherapeutic drug of OV. Most patients initially show response to chemotherapy, but more than 70% will develop recurrent disease in three years [ 2 ]. Chemoresistance limits the survival of patients with advanced cancer who receive chemotherapy [ 3 ]. how many days is the lunar cycleWebSep 30, 2014 · The lack of normal ERCC2 function may contribute to cisplatin sensitivity in urothelial cancer, and somatic ERCC2 mutation status may inform cisplatin-containing regimen usage in muscle-invasive urothelial carcinoma. how many days is the moon fullWebNov 15, 1987 · Two sublines were derived from a human bladder carcinoma continuous cell line (RT112-P), one by exposure to fractionated X-irradiation (RT112-DXR8) and the other by continuous exposure to cisplatin (RT112-CP). RT112-DXR8 cells were 1.6- to 2-fold more sensitive to cisplatin and 2 analogues, carbopla … how many days is the nba seasonWebJul 14, 2024 · Mechanismly, propofol enhances cisplatin sensitivity of NSCLC through miR-486-5p/RAP1-NF-κB axis. The finding provides a deeper understanding about the molecular mechanism of propofol in the platinum resistance of NSCLC, and might support the application of propofol in NSCLC chemotherapy. Materials and methods Cells culture high speed metal air sawWebDetermining the factors that influence cellular sensitivity to cisplatin is thus important for understanding the anticancer activity of cisplatin and for developing a more effective platinum-based chemotherapy. The cytotoxicity of cisplatin arises from its ability to react with DNA and form covalent DNA adducts ( 4 ). high speed metal cutting bandsaw bladeWebCarboplatin sIgE is very specific but less sensitive. In contrast, oxaliplatin sIgE had higher sensitivity but lower specificity. Analysis of our data suggests that oxaliplatin exposure … how many days is the tribulation