Context sensitive half time calculator

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August undefined, 2024

WebAug 8, 2024 · Compartment distribution and context-sensitive half time Fentanyl is widely and rapidly distributed, accumulating in tissues with sustained infusion Because of tissue compartment distribution, context-sensitive half time for fentanyl is markedly prolonged following a long course of use as analgo-sedation (eg. after a 4-hour infusion, context ... WebMar 22, 2012 · Context-Sensitive Half-Time (cont.) • Alfentanil – studied for ambulatory techniques • Elimination half – life: 111 min. • Small distribution volume – not significant in plasma decay after infusion • Sufentanil – elimin. half – life: 577 min. • Less context-sensitive half-time (for infusions up to 8 hours); large volume of ...

Context-sensitive half-times and other decrement times of …

WebEdit. View history. Context-sensitive half-life or context sensitive half-time is defined as the time taken for blood plasma concentration of a drug to decline by one half after an infusion designed to maintain a steady state (i.e. a constant plasma concentration) has been stopped. The "context" is the duration of infusion. WebThe context-sensitive half-time is derived from computer modelling using known pharmacokinetic parameters. The modelled context-sensitive half-time for a 3-h infusion of alfentanil is 50–55 min and is 3 min for remifentanil. The terminal elimination half-life is 111 min for alfentanil and 12–30 min for remifentanil. firm ato

Concepts of Pharmacology - Half Life Calculation

WebSep 13, 2012 · The context-sensitive half-time is the time required for blood or plasma concentrations of a drug to decrease by 50% after discontinuation of drug administration. The context-sensitive half-time often cannot be predicted by the elimination half-life (a measure of the time needed for actual drug metabolism or elimination) since it also … WebThe context-sensitive half-time is derived from computer modelling using known pharmacokinetic parameters. The modelled context-sensitive half-time for a 3-h … WebEdit. View history. Context-sensitive half-life or context sensitive half-time is defined as the time taken for blood plasma concentration of a drug to decline by one half after an … eugenics and abortion connection

Half-life and context-sensitive half-life - Essential Equations for ...

Dexmedetomidine • LITFL • CCC Pharmacology

WebJan 15, 2024 · The “context-sensitive half-time” [73, 84] is a useful way to consider the plasma pharmacokinetic portion of the offset time, as shown in Fig. 18.4. The x-axis on Fig. 18.4 is the duration of an infusion that maintains a … WebAug 16, 2003 · The 50% decrease in drug concentration after the end of administration was more predicted by the context-sensitive half-time than by the elimination half-life. By computer simulations of sufentanil decay Shafer et al [ 18 ]. calculated that a 50% decrease in the effect-site concentration would take 0.8 h after a 10 h infusion. eugenics and cloningWebJun 1, 2004 · Propofol has a context-sensitive half-time that varies between 3 min for a very short infusion to about 18 min after a 12-h … firmato online

"WebJul 5, 2014 · Half-life and context-sensitive half-life; Edward T. Gilbert-Kawai, University College London, Marc D. Wittenberg, University College London; Book: Essential … " - Context sensitive half time calculator

Context sensitive half time calculator

Perioperative Applications of Dexmedetomidine : WFSA - Resources

WebAfter the infusion is discontinued, the time for the concentration to decrease by 50%(the context-sensitive half-life) increases from 1.5 h after a 12-hour infusion to 4.2 h after a 72-hour infusion. Based on Table 5 , to maintain a sedation score of 5, the midazolam infusion at arrival in the surgical ICU should be started at a rate of 3 mg/h. WebThe elimination half-life is 11.5 h and the plasma clearance value is 150 mL/min. The elimination half life of phenobarbital is shorter (6.1 +1- 3.3 hours) in infants and children, …

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WebApr 5, 2024 · The estimated context-sensitive half time of dexmedetomidine is favourably short at between 1 and 4 hours. 3 Thus, the elimination half-life is similar following a single dose or infusions of more than 24 hours. A summary of the pharmacokinetics of dexmedetomidine can be found in Table 1. WebMay 13, 2015 · Understanding methadone half-life allows clinicians to prescribe the proper dosage of the drug to individuals recovering from opioid addiction. SAMHSA states, “Methadone is a long-acting medication with …

WebUsing pharmacokinetic-pharmacodynamic models, computer simulations based on changes in the effect site opioid concentration or context-sensitive half-times seem to be … WebThis has been explored in detail for I.V. anesthetics using computer simulation to calculate context-sensitive half-times (the time needed for a 50% decrease in anesthetic …

WebSep 7, 2004 · – Derive the volume of distribution (Vd), clearance (CL), elimination half-life (t½) and the elimination rate constant (K) – What is the context-sensitive half time? – Discuss how to calculate dosing intervals in relation to the data derived. – Discuss one-, two- and three-compartment models, comparing muscle relaxants and propofol WebThe context-sensitive half-time often cannot be predicted by the elimination half-life (a measure of the time needed for actual drug metabolism or elimination) since it also depends on drug distribution. The context-sensitive half-time is a function of the duration of drug administration and may only be estimated by computer simulation.

WebElimination – metabolites excreted renally (95%) and in faeces (4%); context-sensitive half-life varies from 4 min for a 10 min infusion to 250 min for an 8 h infusion; ... Bellomo …

firma tinoWebAug 16, 2003 · The 50% decrease in drug concentration after the end of administration was more predicted by the context-sensitive half-time than by the elimination half-life. By … eugenics and birth controlWebThis has been explored in detail for I.V. anesthetics using computer simulation to calculate context-sensitive half-times (the time needed for a 50% decrease in anesthetic concentration) and other decrement times (such as the times needed for 80% or 90% decreases in anesthetic concentration). ... reaching plateaus of approximately 30 and 35 … eugenics and genetic engineeringWebOct 22, 2024 · Context-sensitive half time is the concept which relates the drug distribution into and out of tissue compartments to the change in plasma concentration after sustained infusion. If the infusion has not … eugenics 19th centuryWebCSHT（context sensitive half-time）とは、状況依存の半減期の意味で、薬力学において、ある薬剤の持続投与を中止した後、血中濃度が50%に低下するまでの時間を示す指標である。投与が停止された後に定常状態（つまり、一定の血漿濃度）を維持するよう薬物の血漿濃度が半分に低下するのにかかる ... eugenics and ivfWebJun 30, 2015 · This chapter answers parts from Section B(v) of the 2024 CICM Primary Syllabus, which expects the exam candidate to "describe the concepts of effect-site and … firma toolytechWebContext-sensitive half-time provides more useful information under these circumstances. If a drug is given as a constant rate infusion, steady-state concentration will only be achieved after four to five half-lives. Partial pressure largely determines the behaviour of … eugenics and euthanasia